Gregory Jay, Ph.D., M.D. - Associate Professor of Medicine and Engineering, Brown University and Attending Physician, Rhode Island Hospital

Dr. Gregory Jay is an Associate Professor in the Department of Emergency Medicine and in the Division of Engineering. Greg is internationally renowned for his work on joint lubrication in confirming the existence of a synovial fluid lubricant which has been designated by the name "Lubricin", and linking its existence to the gene that codes for megakaryocyte stimulating factor. His subsequent studies have implicated both serine and cysteine proteases in the catabolism of this important protein which endows articular cartilage with the lowest coefficient of friction in nature. Presently, Greg’s work is focused on determining whether increased friction resulting from loss of this protein is involved in the pathogenesis of early osteoarthritis. His work has been funded by both the National Institute on Aging and the National Institute of Arthritis and Musculoskeletal and Skin Diseases. Greg is a practicing Emergency Physician in the Bridge ED and remains engaged in applied biomedical engineering efforts in the treatment of patients with asthma, anemia and carbon monoxide poisoning. Noteworthy are his efforts to create a continuous pulsus paradoxus monitor as a vital sign in the triage of patients with dyspnea, which is supported by the National Heart, Lung and Blood Institute. Greg received the Young Investigator Award from the Society for Academic Emergency Medicine in 2000 and the Bruce Selya Award in 2004.