James Padbury, M.D. - Pediatrician-in-Chief, Women & Infants Hospital and Professor & Vice Chair of Pediatrics, Brown University School of Medicine

Jim Padbury's laboratory is interested in the developmental regulation of expression of the beta 1 Adrenergic Receptor, Placental Biogenic Amine Transporters and IL-10. Each of these genes has novel, developmental modes of regulation that are highly relevant to successful intrauterine growth and development. Jim will speak on Insights into Cardiac Regeneration from a Developmental Model. The beta 1 Adrenergic Receptor is most highly expressed in the myocardium, and the activity of this receptor is tightly regulated; its deregulation results in cardiac hypertrophy and congestive heart failure. Therefore, understanding the regulation of this gene is important and Jim’s group has cloned this gene and has identified a possible mechanism to regulate the cardiac cell cycle.

He has been Professor and Vice Chair of Pediatrics at the Brown University School of Medicine since 1995. Jim is also currently the Pediatrician-in-Chief at the Women & Infants Hospital and Program Director of the COBRE for Perinatal Biology. Jim is a member of the Faculty Executive Committee and the Medical Faculty Executive Committee at Women and Infants Hospital of RI and Brown University, respectively. He is currently on the editorial Board of the Journal of Pediatrics and is an editorial reviewer for multiple journals including the Journal of Pharmacology & Experimental Therapeutics and the Journal of Clinical Endocrinology & Metabolism.  Jim is also the Chair of the Pregnancy and Neonatology Study Section for the National Institutes of Health.